Antioxidants Do Not Lower Cholesterol
In a study of cholesterol-lowering drugs with or without antioxidants, the drugs simvastatin (brand name Zocor) plus niacin reduced serum lipids and heart disease. An antioxidant mixture did not have the same effects. When the antioxidants were combined with the cholesterol-lowering drugs, the beneficial effect was greatly decreased.
The antioxidant mix included 800 IU of vitamin E, 1000 mg of vitamin C, 25 mg of beta-carotene, and 100 micrograms of selenium. In addition to serum lipids, arteriography was performed to determine blockages of coronary arteries, and cardiovascular events (heart attack, stroke, vascular surgery, death) were counted.
Groups of 33 to 40 patients who had low HDL cholesterol (the protective variety) and evidence of heart disease were treated for three years, according to the New England Journal of Medicine (Vol 345:1583-1592).
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