Avoid Altitude Sickness with Antioxidant Vitamin Supplementation
In a randomised, placebo-controlled trial , 18 subjects ascending to Mt. Everest base camp (approximately 5,180 metres above sea level) were given supplementation for three weeks at sea level and then during the 10 day climb to high altitude. The active treatment given was a mixture of vitamin C (L-ascorbic acid 250 mg), vitamin E (dl-alpha-tocopherol acetate 100 IU) and alpha-lipoic acid (150 mg).
The presence of acute mountain sickness (AMS) symptoms was assessed using a standard self-reported measure (Lake Louise AMS score). Results showed that the antioxidant supplemented group had a significantly lower level of AMS at high altitude, compared to the placebo group.
They also had higher resting arterial oxygen saturation (89% versus 85%, p = 0.042), and higher caloric intake (13.2 versus 10.1 MJ/day, p = 0.001). The higher caloric intake appeared to be related to a lower level of satiety following a standardized meal, according to the High Alt Med Biol (2001;2:21-9).
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