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Researchers at the University of Hawaii conducted a study involving 3572 Japanese/American men between the ages of 71 and 93 years to study the link between cholesterol levels and mortality rates.

The researchers found that cholesterol levels tended to decline with age from an average of 5.0 mmol/L (195 mg/dL) in those aged 71 to 74 years to an average of 4.61 mmol/L (180 mg/dL) in those older than 85 years. They also observed that study participants who had maintained low cholesterol levels for 20 years or more had the highest mortality of all.

Subjects had their cholesterol levels and numerous other parameters measured in 1991-93. By December 1996 there had been 727 deaths in the group. The researchers found that men with an average total cholesterol level of 5.99 mmol/L (235 mg/dL) had a 35 percent lower mortality rate (adjusted for age) than did men with an average cholesterol level of 3.85 mmol/L (150 mg/dL). The correlation between mortality and cholesterol levels was not changed after adjusting for other variables that could affect mortality rates.

Details of the study can be obtained from Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study by Schatz, Irwin J., et al from The Lancet (Vol. 358, August 4, 2001, pp. 351-55).