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Researchers at the University of Iowa report that vitamin E has a similar beneficial effect. Their randomized, double-blind, placebo-controlled clinical trial involved 10 healthy volunteers who each went through the four phases of the trial separated by at least a one-week washout period. The four experimental protocols were: oral placebo at 7 am, L-methionine, 100 mg/kg bodyweight at 7 am, vitamin E, 1200 IU at midnight followed by placebo at 7 am and vitamin E, 1200 IU at midnight followed by methionine at 7 a.m.

L-methionine is known to sharply increase blood levels of homocysteine. The blood level of homocysteine and blood flow through the forearm was measured six to eight hours after placebo or methionine administration. The forearm blood flow was measured after an infusion of acetylcholine or bradykinin to simulate the body's normal way of ensuring adequate blood flow.

The researchers found that the high homocysteine levels caused by the methionine administration very significantly lowered blood flow. The effect was completely eliminated when vitamin E had been previously administered. They conclude that vitamin E, like vitamin C effectively reverses the endothelial dysfunction caused by high homocysteine levels.

The results can be found in Effect of vitamin E on resistance vessel endothelial dysfunction induced by methionine by Raghuveer, Geetha, et al published in the American Journal of Cardiology (Vol. 88, August 1, 2001, pp. 285-90).