Trouble with Cloning
About 98 percent of cloned animals don't make it and the survivors are usually abnormally obese. Recent evidence helps explain why cloning attempts fail and produce irregular animals.
Rudolf Jaenisch, a biologist from the Whitehead Institute at the Massachusetts Institute of Technology, led a research team in analyzing the genes in cloned mice. They found while clones showed no clear flaws in their genetic make-up, the mice did have problems expressing their normal genes.
Contrary to expectation, the cloning process wasn't the cause of this gene expression problem. Instead, the problem is traced back to the original stem cells that are used to help create the cloned mice.
The cloning process is well practiced today and has been around for five years. It works by scientists inserting a cell, with its genetic material removed, from an adult into an egg. The egg then reprograms the adult cell to develop into an embryo. Eventually, a genetic identical to the original is produced. Previous research has proved cloning produces extremely overweight animals, sometimes with abnormally large hearts and lungs as explained in The Science, (2001;293:95-97).
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