Growth Hormone Binding Protein - HGHBaumann G. Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine and Veterans Administration, Chicago Health Care System, Chicago, IL 60611, USA. gbaumann@northwestern.edu The high affinity growth hormone binding protein (GHBP), the soluble ectodomain of the growth hormone receptor (GHR), is an integral part of the growth hormone (GH)-insulin-like growth factor axis. Depending on the species, it is either a cleavage product of the GHR or a splice variant of the Ghr gene. GHR cleavage/GHBP shedding is effected by TACE (TNF-alpha converting enzyme), a metalloproteinase of the ADAM family, and possibly related enzymes. The GHBP modulates GH action through both inhibitory and enhancing mechanisms. Because of its complex in vivo effects, the biological role of the GHBP is still incompletely understood. The main clinical application of GHBP measurements is in the diagnosis of genetic growth hormone insensitivity (Laron syndrome). Publication Types:
Get the facts about HGH Releasers Click here to Buy HGH Human Growth Hormone
|
Terms of Use - Privacy
Policy
Disclaimer: Content on this site is
for reference purposes and is not intended to substitute for
advice given by a physician, pharmacist, or other licensed
health-care professional. You should not use this information as
self-diagnosis or for treating a health problem or disease.
Links and content located on other sites is not our
responsibility. Do your own due diligence before purchasing any
product. Contact your health-care provider immediately if you
suspect that you have a medical problem. Information and
statements regarding dietary supplements have not been evaluated
by the Food and Drug Administration and are not intended to
diagnose, treat, cure, or prevent any disease or health
condition.