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Factors influencing HGH response.
Groisne C, Trivin C, Souberbielle JC, Brauner R.
Pediatric Endocrinology Department, Universite Rene-Descartes and
Hopital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris,
France.
OBJECTIVE: To evaluate the factors influencing the growth hormone (GH)
response to GH-releasing hormone (GHRH) test in idiopathic GH
deficiency. METHODS: 28 patients aged 4.9 +/- 0.7 years with certain GH
deficiency were given GHRH (2 microg/kg). RESULTS: The GH peak after
GHRH was correlated negatively with age at evaluation (r = -0.37, p <
0.05) and body mass index (r = -0.44, p = 0.02), and positively with
anterior pituitary height (r = 0.47, p = 0.02), GH peak after non-GHRH
stimulation (r = 0.78, p < 0.0001) and spontaneous GH peak (r = 0.82,
p = 0.007). It was lower in the patients aged >5 years than in the
youngest (p = 0.04), but it was similar in the patients with and without
features suggesting a hypothalamic origin. CONCLUSION: The GH response
to GHRH test cannot be used to differentiate between hypothalamic and
pituitary forms of idiopathic GH deficiency, probably because the GH
response decreases after the first 5 years of life, whatever the origin
of the deficiency. Copyright 2002 S. Karger AG, Basel
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