HGH, Human Growth Hormone effect on men over 60 years old
D Rudman, AG Feller, HS Nagraj, GA
Gergans, PY Lalitha, AF Goldberg, RA Schlenker, L Cohn, IW Rudman, and
DE Mattson
ABSTRACT Background The declining
activity of the growth hormoneinsulin-like growth factor I
(IGF-I) axis with advancing age may contribute to the
decrease in lean body mass and the increase in mass of adipose
tissue that occur with aging.
Methods To test this hypothesis, we studied 21 healthy men
from 61 to 81 years old who had plasma IGF-I concentrations
of less than 350 U per liter during a six-month base-line
period and a six-month treatment period that followed. During
the treatment period, 12 men (group 1) received approximately
0.03 mg of biosynthetic human growth hormone per kilogram of
body weight subcutaneously three times a week, and 9 men
(group 2) received no treatment. Plasma IGF-I levels were
measured monthly. At the end of each period we measured lean
body mass, the mass of adipose tissue, skin thickness
(epidermis plus dermis), and bone density at nine skeletal
sites.
Results In group 1, the mean plasma IGF-I level rose into the
youthful range of 500 to 1500 U per liter during treatment, whereas
in group 2 it remained below 350 U per liter. The administration of
human growth hormone for six months in group 1 was accompanied by
an 8.8 percent increase in lean body mass, a 14.4 percent decrease
in adipose-tissue mass, and a 1.6 percent increase in average
lumbar vertebral bone density (P<0.05 in each instance).
Skin thickness increased 7.1 percent (P=0.07). There was no
significant change in the bone density of the radius or
proximal femur. In group 2 there was no significant change in
lean body mass, the mass of adipose tissue, skin thickness, or
bone density during treatment.
Conclusions Diminished secretion of growth hormone is
responsible in part for the decrease of lean body mass, the
expansion of adipose-tissue mass, and the thinning of the
skin that occur in old age. (N Engl J Med 1990; 323:1-6.)
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